1 (Dame) (in the UK) the title given to a woman with the rank of Knight Commander or holder of the Grand Cross in the Orders of Chivalry:Dame Vera Lynn
2 archaic or humorous an elderly or mature woman:a matronly dame presided at the table
North American informal a woman:a rich dame who took her husband to the cleaners
(also pantomime dame)British a comic middle-aged female character in modern pantomime, usually played by a man.